Wednesday, February 22, 2012

Due to the strong correlation of pla-type...

Klebsiella pneumonia

outpatient festering abscesses of liver (PLA) is a new infectious disease.


RmpA henotype), reportedly associated with the PLA prevalence studies. NTUH-K2044, K1 PLA isolate, carrying three


rmpA/A2 gene: two large plasmids carried genes (p-rmpA and p-rmpA2) and a chromosomal gene (C-rmpA). In this study, we have reviewed the role of


rmpA/A2 in the pathogenesis of PLA to clarify the relationship and capsular serotype rmpA/A2 in virulence. Using isogenic gene deletion strains and complemented strains NTUH-K2044, we have shown that only


r-


rmpA increased expression of capsular polysaccharide synthesis (CPS) gene and production of capsules. However, the lethal dose and


in vivo competition index showed that p-rmpA does not contribute to virulence in mice. The prevalence of these focused on three


rmpA/A2 and capsule type in 206 strains studied. It was marked correlation


rmpA/A2 six PLA related capsule-type (K1, K2, K5, K54, K57 and KN1). However, the value


rmpA/A2 with K1 strains from the West was less obvious than the strains from Asia (17/22 to 39/39


P = 0. 0019). Also focused on three


rmpA/A2 genes, r-


rmpA was the most common. Due to the strong correlation of PLA-type capsule-related, r-


rmpA can serve as a surrogate marker for PLA. We found a relationship p-


rmpA with three wide-set loci in large plasmids (30/32). Therefore


rmpA can share with inherited strattera dosage virulence genes, which carries this plasmid. .

No comments:

Post a Comment